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. 2014 Jan 3;9(1):1.
doi: 10.1186/1749-8546-9-1.

Identifying the Zheng in psoriatic patients based on latent class analysis of traditional Chinese medicine symptoms and signs

Xuesong Yang, Virasakdi Chongsuvivatwong, Sanguan Lerkiatbundit, Jianzhou Ye, Xiaoyong Ouyang, Enpin Yang, Hutcha Sriplung  1
Affiliations

Identifying the Zheng in psoriatic patients based on latent class analysis of traditional Chinese medicine symptoms and signs

Xuesong Yang et al. Chin Med. .

Abstract

Background: There are approximately five Zhengs reported in psoriatic patients. Systematic data collection and proper analysis for the classification of psoriasis have been lacking. This study aims to cluster the Zhengs in psoriatic patients based on the application of a checklist of traditional Chinese medicine (TCM) symptoms and signs followed by latent class analysis (LCA).

Methods: A cross-sectional study of 507 psoriatic patients aged above 10 years was performed in Yunnan Provincial Hospital of TCM and the First Affiliated Hospital of Kunming Medicine University from October 2010 to September 2011 using a TCM symptoms and signs checklist obtained from 16 TCM experts by the Delphi technique. LCA was applied to obtain the best fitted model for clustering of symptoms and signs that can be interpreted as underlying Zhengs of psoriasis.

Results: The LCA identified three Zhengs: dampness-heat Zheng (35.1%); blood heat Zheng (34.7%); and yin deficiency and blood dryness Zheng (30.2%). The first Zheng was associated with winter, the second with male sex, old age, smoking, and drinking alcohol, and the third with outpatient status, which reflected a mild disease course.

Conclusions: In this study, 507 psoriasis patients were clustered into three Zhengs, which had different associated factors.

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References

    1. Naldi L. Psoriasis. Dermatol Clin. 1995;13:635–647. - PubMed
    1. Naldi L. Epidemiology of psoriasis. Curr Drug Targets Inflamm Allergy. 2004;3:121–128. doi: 10.2174/1568010043343958. - DOI - PubMed
    1. Qureshi A, Choi HK, Setty AR, Curhan GC. Psoriasis and the risk of diabetes and hypertension: a prospective study of US female nurses. Arch Dermatol. 2009;145:379–382. - PMC - PubMed
    1. Mehta NN, Azfar RS, Shin DB, Neimann AL, Troxel AB, Gelfand JM. Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the general practice research database. Eur Heart J. 2010;31:1000–1006. doi: 10.1093/eurheartj/ehp567. - DOI - PMC - PubMed
    1. Kurd SK, Troxel AB, Crits-Christoph P, Gelfand JM. The risk of depression, anxiety and suicidality in patients with psoriasis: a population-based cohort study. Arch Dermatol. 2010;146:891–895. - PMC - PubMed

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