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. 2014 Feb;21(1):55-65.
doi: 10.1016/j.pathophys.2013.11.010. Epub 2013 Dec 31.

Inflammatory signaling in NEC: Role of NF-κB, cytokines and other inflammatory mediators

Catherine J Hunter  1 , Isabelle G De Plaen  2
Affiliations

Inflammatory signaling in NEC: Role of NF-κB, cytokines and other inflammatory mediators

Catherine J Hunter et al. Pathophysiology. 2014 Feb.
No abstract available

Keywords: Inflammatory cell; LPS; Murine model; Necrotizing enterocolitis; PAF; Toll-like receptors.

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Figures

Fig. 1
Fig. 1
Signaling events leading to NF-κB activation
Fig. 2
Fig. 2
Role of nitric oxide in vivo
Fig. 3
Fig. 3
Schematic representation of the pathogenetic events leading to NEC
See this image and copyright information in PMC

References

    1. Wang Y, Hoenig JD, Malin KJ, Qamar S, Petrof EO, Sun J, Antonopoulos DA, Chang EB, Claud EC. 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis. The ISME journal. 2009;3:944–954. - PMC - PubMed
    1. Dinsmore JE, Jackson RJ, Smith SD. The protective role of gastric acidity in neonatal bacterial translocation. J Pediatr Surg. 1997;32:1014–1016. - PubMed
    1. Rozenfeld RA, Liu X, DePlaen I, Hsueh W. Role of gut flora on intestinal group II phospholipase A2 activity and intestinal injury in shock. Am J Physiol Gastrointest Liver Physiol. 2001;281:G957–G963. - PubMed
    1. Carlisle EM, Poroyko V, Caplan MS, Alverdy JA, Liu D. Gram negative bacteria are associated with the early stages of necrotizing enterocolitis. PloS one. 2011;6:e18084. - PMC - PubMed
    1. Essani NA, McGuire GM, Manning AM, Jaeschke H. Endotoxin-induced activation of the nuclear transcription factor kappa B and expression of E-selectin messenger RNA in hepatocytes, Kupffer cells, and endothelial cells in vivo. J Immunol. 1996;156:2956–2963. - PubMed