The race for regeneration: Pluripotent-stem-cell-derived 3D kidney structures
- PMID: 24388170
- PMCID: PMC4058857
- DOI: 10.1016/j.stem.2013.12.004
The race for regeneration: Pluripotent-stem-cell-derived 3D kidney structures
Abstract
The kidney's complex spatial organization and poorly defined lineage specification programs have impeded derivation of kidney progenitors from pluripotent stem cells (PSCs). Now in Cell Stem Cell, Taguchi et al. (2014) redefine the identity of embryonic kidney progenitors in vivo to obtain PSC-derived kidney progenitors that can form nephrons in vivo.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells.Cell Stem Cell. 2014 Jan 2;14(1):53-67. doi: 10.1016/j.stem.2013.11.010. Epub 2013 Dec 12. Cell Stem Cell. 2014. PMID: 24332837
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- Harari-Steinberg O, Metsuyanim S, Omer D, Gnatek Y, Gershon R, Pri-Chen S, Ozdemir DD, Lerenthal Y, Noiman T, Ben-Hur H, et al. Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease. EMBO Mol Med. 2013;5:1556–1568. - PMC - PubMed
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- Saxen L, Sariola H. Early organogenesis of the kidney. Pediatr Nephrol. 1987;1:385–392. - PubMed
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- Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H, Nishinakamura R. Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell. 2014;14 XXXXX-XXXXX. - PubMed
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