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Comment
. 2014 Jan 2;14(1):6-8.
doi: 10.1016/j.stem.2013.12.009.

Hippo tips the TGF-β scale in favor of pluripotency

Alan C Mullen  1
Affiliations
Comment

Hippo tips the TGF-β scale in favor of pluripotency

Alan C Mullen. Cell Stem Cell. .

Abstract

How TGF-β signaling switches from enforcing pluripotency to promoting mesendodermal differentiation remains an open question. Recently in Cell Reports, Beyer et al. demonstrated that Hippo signaling components recruit the NuRD complex to repress expression of key genes targeted by TGF-β and thus determine whether TGF-β signaling will favor pluripotency or differentiation.

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Figures

Figure 1
Figure 1. Loss of TAZ/YAP and TEAD results in activation of mesendodermal genes bound by SMAD2/3
A set of key mesendodermal genes are bound by OCT4, SMAD2/3, SMAD4, FOXH1, TAZ/YAP and TEAD family members in hESCs. These genes are repressed in hESCs where TAZ/YAP and TEAD act to recruit the NuRD complex (left). With mesendodermal differentiation, TAZ/YAP and TEAD no longer bind key mesendodermal genes. In their absence the NuRD complex is released and mesendodermal genes are activated in a process that is dependent on SMAD2/3 and FOXH1 (right).
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References

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