Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Jan 1;10(1):6-8.
doi: 10.4161/org.27487. Epub 2014 Jan 3.

Building stable anisotropic tissues using cellular collagen gels

James B Phillips  1
Affiliations
Comment

Building stable anisotropic tissues using cellular collagen gels

James B Phillips. Organogenesis. .

Abstract

Combining cellular self-alignment within tethered collagen gels with stabilization through subsequent removal of interstitial fluid has yielded a new process for the fabrication of aligned cellular biomaterials. This commentary discusses the generation of engineered neural tissue for peripheral nerve repair using this combination of techniques, providing additional insight into the rationale underpinning the approach. By describing the potential benefits of using cell and matrix interactions to organize 3D hydrogels that can be stabilized to form tissue-like constructs, the article aims to highlight the potential for the approach to be used in the generation of a wider range of functional replacement tissues.

Keywords: Schwann cell; alignment; anisotropy; biomaterials; collagen; hydrogel; nerve; regenerative medicine; tissue engineering.

PubMed Disclaimer

Comment on

  • Engineered neural tissue for peripheral nerve repair.
    Georgiou M, Bunting SC, Davies HA, Loughlin AJ, Golding JP, Phillips JB. Georgiou M, et al. Biomaterials. 2013 Oct;34(30):7335-43. doi: 10.1016/j.biomaterials.2013.06.025. Epub 2013 Jul 5. Biomaterials. 2013. PMID: 23834895

References

    1. Georgiou M, Bunting SC, Davies HA, Loughlin AJ, Golding JP, Phillips JB. Engineered neural tissue for peripheral nerve repair. Biomaterials. 2013;34:7335–43. doi: 10.1016/j.biomaterials.2013.06.025. - DOI - PubMed
    1. Brown RA, Phillips JB. Cell responses to biomimetic protein scaffolds used in tissue repair and engineering. Int Rev Cytol. 2007;262:75–150. doi: 10.1016/S0074-7696(07)62002-6. - DOI - PubMed
    1. Park H, Cannizzaro C, Vunjak-Novakovic G, Langer R, Vacanti CA, Farokhzad OC. Nanofabrication and microfabrication of functional materials for tissue engineering. Tissue Eng. 2007;13:1867–77. doi: 10.1089/ten.2006.0198. - DOI - PubMed
    1. Lim JY, Donahue HJ. Cell sensing and response to micro- and nanostructured surfaces produced by chemical and topographic patterning. Tissue Eng. 2007;13:1879–91. doi: 10.1089/ten.2006.0154. - DOI - PubMed
    1. Bettinger CJ, Langer R, Borenstein JT. Engineering substrate topography at the micro- and nanoscale to control cell function. Angew Chem Int Ed Engl. 2009;48:5406–15. doi: 10.1002/anie.200805179. - DOI - PMC - PubMed

LinkOut - more resources