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Randomized Controlled Trial
. 2014 Jun;8(2):260-8.
doi: 10.1007/s11764-013-0337-z. Epub 2014 Jan 4.

Influence of weight training on skeletal health of breast cancer survivors with or at risk for breast cancer-related lymphedema

Kerri M Winters-Stone  1 , Monica Laudermilk, Kaitlin Woo, Justin C Brown, Kathryn H Schmitz
Affiliations
Randomized Controlled Trial

Influence of weight training on skeletal health of breast cancer survivors with or at risk for breast cancer-related lymphedema

Kerri M Winters-Stone et al. J Cancer Surviv. 2014 Jun.

Abstract

Purpose: This study aimed to determine whether the Physical Activity and Lymphedema (PAL) trial weight training program for breast cancer survivors at risk of or with breast cancer-related lymphedema provided skeletal benefits.

Methods: Of the 295 participants in the randomized controlled PAL trial, 258 (weight training; N = 128; control, N = 130) had complete measures of bone mineral density (BMD (in grams per square centimeter)) of the proximal femur and lumbar spine and were also categorized by T scores. Women in the weight training group performed slowly progressive weight training 2 days/week for 12 months compared to women in the control group who maintained their usual physical activities.

Results: There were no significant differences in the rate of BMD change at any skeletal site between weight training and control groups, regardless of menopausal status. Distribution of bone health categories was not significantly different between groups at baseline, but became different at 12 months (p < 0.03) among postmenopausal women due to an increase in the percentage of controls who became osteopenic (35 to 44%) compared to stable bone health in weight lifters.

Conclusions: The PAL weight training program that increased muscle strength without exacerbating or causing lymphedema among breast cancer survivors was not as efficacious at improving skeletal health. The skeletal loads produced from the PAL program may be insufficient to notably shift BMD, but may have a subtle osteogenic effect.

Implications for cancer survivors: The safety and efficacy of rigorous weight training programs for improving skeletal health in women at risk for or with breast cancer-related lymphedema remain to be determined.

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Conflict of interest statement

Conflict of Interest

The authors have no disclosures to report.

Figures

Fig 1
Fig 1
Flow of participants in the PAL trial and availability of DXA data for analysis
See this image and copyright information in PMC

References

    1. Chen ZMM, Aragaki AK, Mouton C, Arendell L, Lopez AM, Bassford T, Chlebowski RT. Fracture risk increases after diagnosis of breast or other cancers in postmenopausal women: results from the Women's Health Initiative. Osteoporos Int. 2009;20(4):527–536. - PMC - PubMed
    1. Sweeney C, Schmitz KH, Lazovich D, Virnig BA, Wallace RB, Folsom AR. Functional Limitations in Elderly Female Cancer Survivors. J Natl Cancer Inst. 2006;98(8):521–529. - PubMed
    1. Vance V, Mourtzakis M, McCargar L, Hanning R. Weight gain in breast cancer survivors: prevalence, pattern and health consequences. Obesity Rev. 2011;12(4):282–294. - PubMed
    1. Santen RJ. Effect of Endocrine Therapies on Bone in Breast Cancer Patients. J Clin Endocrinol Metab. 2011;96(2):308–319. - PubMed
    1. Cameron D, Douglas S, Brown J, Anderson R. Bone mineral density loss during adjuvant chemotherapy in pre-menopausal women with early breast cancer: is it dependent on oestrogen deficiency? Breast Cancer Res Treat. 2010;23(3):805–814. - PubMed

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