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. 2013 Dec 3:2013:131358.
doi: 10.1155/2013/131358. eCollection 2013.

Pharmacokinetic delivery and metabolizing rate of nicardipine incorporated in hydrophilic and hydrophobic cyclodextrins using two-compartment mathematical model

Sergey Shityakov  1 , Carola Förster  1
Affiliations

Pharmacokinetic delivery and metabolizing rate of nicardipine incorporated in hydrophilic and hydrophobic cyclodextrins using two-compartment mathematical model

Sergey Shityakov et al. ScientificWorldJournal. .

Abstract

The dispersion routes of cyclodextrin complexes with nicardipine (NC), such as hydrophilic hydroxypropyl-β-cyclodextrin (NC/HPβCD) and hydrophobic triacetyl-β-cyclodextrin (NC/TAβCD), through the body for controlled drug delivery and sustained release have been examined. The two-compartment pharmacokinetic model described the mechanisms of how the human body handles with ingestion of NC-cyclodextrin complexes in gastrointestinal tract (GI), distribution in plasma, and their metabolism in the liver. The model showed that drug bioavailability was significantly improved after oral administration of cyclodextrin complexes. The mathematical significance of this study to predict nicardipine delivery using pharmacokinetic two-compartment mathematical model with linear ordinary differential equations (ODE) approach represents a valuable tool to emphasize its effectiveness and metabolizing rate and diminish the side effects.

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Figures

Figure 1
Figure 1
Loading of long-range GI and plasma concentration-time profiles from a dosage regime for NC (a), NC/HPβCD (b), and NC/TAβCD (c) compounds after oral administration.
Figure 2
Figure 2
{x(t), y(t)} with limit cycle for NC, NC/HPβCD, and NC/TAβCD substances.
Figure 3
Figure 3
Short-range GI (a) and plasma concentration (b) levels for NC, NC/HPβCD, and NC/TAβCD and their metabolizing rates (c) as functions of time using refined rate constants.
Algorithm 1
Algorithm 1
Algorithm 2
Algorithm 2
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References

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