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Meta-Analysis
. 2013 Dec 31;8(12):e85179.
doi: 10.1371/journal.pone.0085179. eCollection 2013.

The role of prostatitis in prostate cancer: meta-analysis

Junyi Jiang  1 , Jinyi Li  2 , Zhang Yunxia  3 , Hong Zhu  1 , Junjiang Liu  3 , Chris Pumill  4
Affiliations
Meta-Analysis

The role of prostatitis in prostate cancer: meta-analysis

Junyi Jiang et al. PLoS One. .

Abstract

Objective: Use systematic review methods to quantify the association between prostatitis and prostate cancer, under both fixed and random effects model.

Evidence acquisition: Case control studies of prostate cancer with information on prostatitis history. All studies published between 1990-2012, were collected to calculate a pooled odds ratio.

Selection criteria: the selection criteria are as follows: human case control studies; published from May 1990 to July 2012; containing number of prostatitis, and prostate cancer cases.

Evidence synthesis: In total, 20 case control studies were included. A significant association between prostatitis and prostate cancer was found, under both fixed effect model (pooled OR=1.50, 95%CI: 1.39-1.62), and random effects model (OR=1.64, 95%CI: 1.36-1.98). Personal interview based case control studies showed a high level of association (fixed effect model: pooled OR=1.59, 95%CI: 1.47-1.73, random effects model: pooled OR= 1.87, 95%CI: 1.52-2.29), compared with clinical based studies (fixed effect model: pooled OR=1.05, 95%CI: 0.86-1.28, random effects model: pooled OR= 0.98, 95%CI: 0.67-1.45). Additionally, pooled ORs, were calculated for each decade. In a fixed effect model: 1990's: OR=1.58, 95% CI: 1.35-1.84; 2000's: OR=1.59, 95% CI: 1.40-1.79; 2010's: OR=1.37, 95% CI: 1.22-1.56. In a random effects model: 1990's: OR=1.98, 95% CI: 1.08-3.62; 2000's: OR=1.64, 95% CI: 1.23-2.19; 2010's: OR=1.34, 95% CI: 1.03-1.73. Finally a meta-analysis stratified by each country was conducted. In fixed effect models, U.S: pooled OR =1.45, 95%CI: 1.34-1.57; China: pooled OR =4.67, 95%CI: 3.08-7.07; Cuba: pooled OR =1.43, 95%CI: 1.00-2.04; Italy: pooled OR =0.61, 95%CI: 0.13-2.90. In random effects model, U.S: pooled OR=1.50, 95%CI: 1.25-1.80; China: pooled OR =4.67, 95%CI: 3.08-7.07; Cuba: pooled OR =1.43, 95%CI: 1.00-2.04; Italy: pooled OR =0.61, 95%CI: 0.13-2.90.

Conclusions: the present meta-analysis provides the statistical evidence that the association between prostatitis and prostate cancer is significant.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. A flow diagram of the study selection process.
Figure 2
Figure 2. Forest plot of odds ratio under fixed effect and random effects model.
Figure 3
Figure 3. Forest plot of odds ratio under fixed effect and random effects model, based on data source.
Figure 4
Figure 4. Forest plot of odds ratio under fixed effect and random effects model, based on decades.
Figure 5
Figure 5. Forest plot of odds ratio under fixed effect and random effects model, based on countries.
Figure 6
Figure 6. Egger’s publication bias plot.
Figure 7
Figure 7. Funnel plot of standard error of log OR over log OR.
See this image and copyright information in PMC

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