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Meta-Analysis
. 2014 Jan 2;9(1):e84251.
doi: 10.1371/journal.pone.0084251. eCollection 2014.

Polymorphisms of C242T and A640G in CYBA gene and the risk of coronary artery disease: a meta-analysis

Qiumei Xu  1 , Fangfen Yuan  2 , Xuemei Shen  2 , Hui Wen  1 , Wei Li  1 , Bei Cheng  1 , Jing Wu  2
Affiliations
Meta-Analysis

Polymorphisms of C242T and A640G in CYBA gene and the risk of coronary artery disease: a meta-analysis

Qiumei Xu et al. PLoS One. .

Abstract

Background: Coronary artery disease (CAD) is a leading cause of mortality in many countries. Considerable studies have been carried out to investigate the relationship between the C242T and A640G polymorphisms of CYBA gene and CAD, but the results were still inconsistent. Hence we conducted a meta-analysis to clarify the association.

Methods and results: A total of 21 eligible literatures were included in the meta-analysis. We observed a significant decreased risk of CAD for C242T polymorphism in Asian population under an allelic model (OR 0.75; 95% CI 0.67-0.84) and a dominant model (OR 0.69; 95% CI 0.61-0.79), however, in overall population and other population no significant association was revealed. We also found A640G polymorphism may contribute to reducing CAD risk under an allelic model (OR 0.84; 95% CI 0.75-0.93), dominant model (OR0.77; 95% CI 0.64-0.92) and recessive model (OR0.82; 95% CI 0.69-0.97). No publication bias was found.

Conclusion: Our meta-analysis confirmed a protective effect of C242T polymorphism on CAD in Asian population and indicated that A640G polymorphism was significantly associated with decreased risk of CAD.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Flow chart of the literature search.
CAD, coronary artery disease.
Figure 2
Figure 2. The forest plots of OR with 95% CI for C242T polymorphism and CAD risk.
OR, Odds ratio; 95% CI, 95% confidence interval; RE, random-effects model; FE, fix-effects model; CAD, coronary artery disease.
Figure 3
Figure 3. The forest plots of OR with 95% CI for A640G polymorphism and CAD risk.
OR, Odds ratio; 95% CI, 95% confidence interval; RE, random-effects model; FE, fix-effects model; CAD, coronary artery disease.
Figure 4
Figure 4. The funnel plots of natural logarithm of OR against inverse standard error in each study.
See this image and copyright information in PMC

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