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Review
. 2012 Feb 1;2(1):1.
doi: 10.1007/s13554-012-0001-6. eCollection 2012.

Treatment of Systemic Juvenile Idiopathic Arthritis with Tocilizumab - the Role of Anti-Interleukin-6 Therapy After a Decade of Treatment

Andreas Reiff  1
Affiliations
Review

Treatment of Systemic Juvenile Idiopathic Arthritis with Tocilizumab - the Role of Anti-Interleukin-6 Therapy After a Decade of Treatment

Andreas Reiff. Biol Ther. .

Abstract

With the recent approval of tocilizumab as the first biologic for the treatment of systemic juvenile idiopathic arthritis (sJIA), an important unmet medical need for this historically challenging disease has now been met. The purpose of this review article is to revisit the established therapeutic options for sJIA, to summarize the history of the clinical trials with tocilizumab, and to discuss its role in the treatment of sJIA.

Keywords: anti-interleukin-6; systemic juvenile idiopathic arthritis; tocilizumab.

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Figures

Fig. 1
Fig. 1
Course of systemic juvenile idiopathic arthritis (sJIA). Although part of a continuous spectrum and variable between patients, sJIA seems to follow a certain cytokine predominance that defines the various disease stages.
See this image and copyright information in PMC

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