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. 2013;1(4):163-8.
doi: 10.12954/PI.13025. Epub 2013 Dec 30.

Ten-core versus 16-core transrectal ultrasonography guided prostate biopsy for detection of prostatic carcinoma: a prospective comparative study in Indian population

V Surya Prakash  1 , G Chandra Mohan  1 , S Venkata Krishnaiah  1 , V Vijaykumar  1 , G Ramesh Babu  1 , G Vijaya Bhaskar Reddy  1 , V S Mahaboob
Affiliations

Ten-core versus 16-core transrectal ultrasonography guided prostate biopsy for detection of prostatic carcinoma: a prospective comparative study in Indian population

V Surya Prakash et al. Prostate Int. 2013.

Abstract

Purpose: To compare the cancer detection rate in patients with raised serum prostate-specific antigen (PSA) or abnormal digital rectal examination (DRE) results between the 10-core and the 16-core biopsy techniques in an Indian population.

Methods: Between November 2010 and November 2012, 95 men aged >50 years who presented to the Urology Department with lower urinary tract symptoms, elevated serum PSA, and/or abnormal DRE findings underwent transrectal ultrasonography (TRUS)-guided prostate biopsy. A total of 53 patients underwent 10-core biopsy and 42 patients underwent 16-core biopsy.

Results: Of the 53 men in the 10-core group, 8 had cancer, whereas in the 16-core biopsy group, 23 of 42 men had cancer. Detection of prostate cancer was significantly higher in patients who underwent 16-core biopsy than in those who underwent 10-core biopsy (P<0.001). Among the 95 men, 44 men had abnormal DRE findings (46.3%), of whom 23 showed cancer (52.27%). Of 51 men with normal DRE findings and elevated PSA, 8 men had malignancy with a cancer detection rate of 15.68%. Among 20 men with PSA between 4.1 and 10 ng/mL, 2 (10%) had cancer. In 31 men with PSA between 10.1 and 20 ng/mL, 3 cancers (9.67%) were detected, and in 44 men with PSA >20 ng/mL, 26 cancers were detected (59.09%).

Conclusions: The cancer detection rate with 16-core TRUS-guided biopsy is significantly higher than that with 10-core biopsy (54.76% vs. 15.09%, P<0.001). In patients with both normal and abnormal DRE findings, 16-core biopsy has a better detection rate than the 10-core biopsy protocol. With increasing PSA, there is a high rate of detection of prostate cancer in both 10-core and 16-core biopsy patients.

Keywords: Digital rectal examination; Prostate biopsy; Prostate neoplasms; Prostate-specific antigen; Transrectal ultrasonography.

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Figures

Fig. 1.
Fig. 1.
Prostate biopsy sites. (A) 10 cores, (B) 16 cores. RP, right periphery; RPM, right paramedian; LP, left periphery; LPM, left paramedian.
Fig. 2.
Fig. 2.
Comparison of 10 cores with 16 cores on prostate cancer detection with rising prostate-specific antigen (PSA).
See this image and copyright information in PMC

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