Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Feb;11(2):73-4.
doi: 10.1038/nrclinonc.2013.243. Epub 2014 Jan 7.

Liver cancer in 2013: Mutational landscape of HCC--the end of the beginning

Augusto Villanueva  1 , Josep M Llovet  2
Affiliations
Review

Liver cancer in 2013: Mutational landscape of HCC--the end of the beginning

Augusto Villanueva et al. Nat Rev Clin Oncol. 2014 Feb.

Abstract

Next-generation sequencing analysis and characterization of the microenvironment ‘field-effect’ that promotes hepatocellular carcinoma (HCC) development has revealed critical players and potential targets for chemoprevention. A biomarker-based drug development strategy is needed to improve future HCC clinical trials and therapies.

PubMed Disclaimer

Conflict of interest statement

Competing interests

A. Villanueva declares an association with the following company: Bayer Pharmaceuticals. J. M. Llovet declares an association with the following companies: Bayer Pharmaceuticals, Blueprint, BMS, Imclone-Lilly, Nanostring, Novartis. See the article online for full details of the relationships.

References

    1. Lonzano R et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2095–2128 (2012). - PMC - PubMed
    1. Cleary SP et al. Identification of driver genes in hepatocellular carcinoma by exome sequencing. Hepatology 10.1002/hep.26540. - DOI - PMC - PubMed
    1. Guichard C et al. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat. Genet. 44, 694–698 (2012). - PMC - PubMed
    1. Kan Z et al. Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. Genome Res. 23, 1422–1433 (2013). - PMC - PubMed
    1. Chiang DY et al. Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. Cancer Res. 68, 6779–6788 (2008). - PMC - PubMed

Publication types

MeSH terms