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. 2014 Mar;347(3):221-8.
doi: 10.1002/ardp.201300299. Epub 2014 Jan 7.

Synthesis, antioxidant, and cytotoxic activities of N-azole substituted thiomorpholine derivatives

Putta Ramachandra Reddy  1 , Guda Mallikarjuna Reddy, Adivireddy Padmaja, Venkatapuram Padmavathi, Paturu Kondaiah, Narra Siva Krishna
Affiliations

Synthesis, antioxidant, and cytotoxic activities of N-azole substituted thiomorpholine derivatives

Putta Ramachandra Reddy et al. Arch Pharm (Weinheim). 2014 Mar.

Abstract

A new class of N-azole substituted thiomorpholine derivatives were prepared and their antioxidant and cytotoxic activities were studied. The methyl substituted oxazolyl thiomorpholine dioxide 9b exhibited radical scavenging activity greater than the standard ascorbic acid. On the other hand, the thiazolyl thiomorpholine 10c having a chloro substituent on the aromatic ring was identified as a remarkable lead molecule for cytotoxic activity against A549 and HeLa cells, with IC50 values of 10.1 and 30.0 µM, respectively.

Keywords: Antioxidant activity; Cytotoxicity; Imidazoles; Oxazoles; Thiazoles; Thiomorpholines.

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