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Comparative Study
. 1987 Jul 1;166(1):95-108.
doi: 10.1084/jem.166.1.95.

Widespread transcription of a Qa region gene in adult mice

M J Palmer, J A Frelinger
Comparative Study

Widespread transcription of a Qa region gene in adult mice

M J Palmer et al. J Exp Med. .

Abstract

The mouse MHC class I family includes genes encoded in four regions: H-2K, H-2D, Qa and Tla. While K/D genes are well characterized, relatively little is known about Qa or Tla genes. We have studied the transcription of a B10.P Qa region gene. DNA sequence comparisons of the transmembrane region, supported by Southern blot analysis of cosmid and genomic DNAs from BALB/c and C57BL/10, demonstrate the lambda 3a gene corresponds to Q4p. In both Northern blots and RNA protection experiments using probes derived from the 3' noncoding region, we found that Q4, like the H-2K and H-2D genes, is widely transcribed in B10.P tissues. These data demonstrate for the first time widespread transcription of a Qa gene.

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References

    1. Nature. 1984 Aug 23-29;310(5979):650-5 - PubMed
    1. Mol Gen Genet. 1984;195(3):491-9 - PubMed
    1. Nucleic Acids Res. 1984 Dec 21;12(24):9473-87 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Feb;82(4):1175-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Mar;82(5):1503-7 - PubMed

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