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. 2014 Feb;7(2):458-460.
doi: 10.3892/ol.2013.1712. Epub 2013 Nov 27.

Extramedullary plasmacytoma of the nasopharynx: A case report and review of the literature

Yen-Liang Chang  1 , Po-Yueh Chen  2 , Shih-Han Hung  3
Affiliations

Extramedullary plasmacytoma of the nasopharynx: A case report and review of the literature

Yen-Liang Chang et al. Oncol Lett. 2014 Feb.

Abstract

Plasmacytoma is an extremely rare and discrete solitary mass of neoplastic monoclonal plasma cells. Extramedullary plasmacytoma (EMP) tends to occur during the fifth and seventh decades of life and is rarely diagnosed in younger patients. Only four cases of EMP have been previously reported in relatively young patients. Here we report a 15-year-old patient presenting with long-term nasal obstruction, who was found to have EMP of the nasopharynx. The patient was treated with surgery followed by radiotherapy with a satisfactory outcome. To the best of our knowledge, this study describes the the youngest individual with nasopharyngeal EMP to be reported in the literature.

Keywords: extramedullary; head and neck; nasopharynx; plasmacytoma.

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Figures

Figure 1
Figure 1
CT revealing a mass (arrow) occupying almost the entire nasopharyngeal space. CT, computed tomography.
Figure 2
Figure 2
Microscopically, the tumor showed sheets of monomorphic round-to-oval cells with nuclear pleomorphism (hematoxylin and eosin; magnification, ×100).
Figure 3
Figure 3
Microscopically, the tumor showed sheets of monomorphic round-to-oval cells (arrows) with nuclear pleomorphism (hematoxylin and eosin; magnification, ×400).
Figure 4
Figure 4
Tumor cells positive for VS38c (magnification, ×400).
See this image and copyright information in PMC

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