Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Jan 21;111(3):889-90.
doi: 10.1073/pnas.1321957111. Epub 2014 Jan 7.

CTCF and cohesin cooperate to organize the 3D structure of the mammalian genome

Laura Baranello  1 , Fedor Kouzine, David Levens
Affiliations
Comment

CTCF and cohesin cooperate to organize the 3D structure of the mammalian genome

Laura Baranello et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
CTCF and cohesin cooperate to organize the 3D structure of the mammalian genome. In the interphase nucleus, individual chromosomes occupy distinct spatial territories (Center). At the subcompartment level, chromatin is organized through megabase-sized interactions called topological domains. Chromatin looping can be the result of nonspecific interactions of the chromatin fiber packing in the crowded nucleus (Left) or of specific contacts between two loci, mediated by protein complexes and the subnuclear structure (Right). Within bounded domains, torsional stress accumulates and affects the expression of neighboring genes. In the central drawing colors represent chromosomal territories.
See this image and copyright information in PMC

Comment on

References

    1. Cremer T, Cremer M. Chromosome territories. Cold Spring Harb Perspect Biol. 2010;2(3):a003889. - PMC - PubMed
    1. Apostolou E, Thanos D. Virus infection induces NF-kappaB-dependent interchromosomal associations mediating monoallelic IFN-beta gene expression. Cell. 2008;134(1):85–96. - PubMed
    1. Bacher CP, et al. Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation. Nat Cell Biol. 2006;8(3):293–299. - PubMed
    1. Kim YJ, Cecchini KR, Kim TH. Conserved, developmentally regulated mechanism couples chromosomal looping and heterochromatin barrier activity at the homeobox gene A locus. Proc Natl Acad Sci USA. 2011;108(18):7391–7396. - PMC - PubMed
    1. Lieberman-Aiden E, et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science. 2009;326(5950):289–293. - PMC - PubMed

LinkOut - more resources