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Review
. 1987;327(6124):677-82.
doi: 10.1038/327677a0.

A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation

Y H Chien, M Iwashima, K B Kaplan, J F Elliott, M M Davis
Review

A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation

Y H Chien et al. Nature. 1987.

Abstract

A new T-cell receptor gene lies just 5' to the J alpha C alpha coding regions. Its placement in this location suggests a novel mechanism for the regulation of expression of one T-cell receptor polypeptide to another during ontogeny. Rearrangement of this locus occurs very early in thymic differentiation and its RNA expression parallels that of the gamma-chain in thymic subpopulations, making this a possible candidate for the recently described delta-chain of the T-cell receptor.

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