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. 2014:5:2870.
doi: 10.1038/ncomms3870.

Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne

Li He  1 , Wen-Juan Wu  1 , Jian-Kang Yang  2 , Hui Cheng  3 , Xian-Bo Zuo  3 , Wei Lai  4 , Tian-Wen Gao  5 , Cui-Lin Ma  5 , Na Luo  6 , Jian-Qing Huang  7 , Feng-Yan Lu  8 , Ye-Qiang Liu  9 , Yi-Jin Huang  10 , Qian-Jin Lu  11 , Huai-Liang Zhang  12 , Lin Wang  13 , Wei-Zhen Wang  14 , Mei-Mei Wang  15 , Sheng-Xiang Xiao  16 , Qing Sun  17 , Chun-Yang Li  17 , Yan-Ping Bai  18 , Hui Li  19 , Zhan-Chao Zhou  20 , Fu-Sheng Zhou  3 , Gang Chen  3 , Bo Liang  3 , Jue Qi  21 , Xiao-Yan Yang  21 , Ting Yang  21 , Xing Zheng  22 , Liang-Dan Sun  3 , Xue-Jun Zhang  3 , Ya-Ping Zhang  22
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Free article

Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne

Li He et al. Nat Commun. 2014.
Free article

Abstract

Severe acne is a chronic inflammatory skin disorder characterized by widespread inflammatory lesions including nodules, cysts and potential scarring. Here we perform the first genome-wide association study of severe acne in a Chinese Han population comprising 1,056 cases and 1,056 controls using the Illumina HumanOmniZhongHua-8 BeadChip. In an independent cohort of 1,860 cases and 3,660 controls of Chinese Han, we replicate 101 SNPs of which 3 showed consistent association. We identify two new susceptibility loci at 11p11.2 (DDB2, rs747650, P(combined)=4.41 × 10⁻⁹ and rs1060573, P(combined)=1.28 × 10⁻⁸) and 1q24.2 (SELL, rs7531806, P(combined)=1.20 × 10⁻⁸) that are involved in androgen metabolism, inflammation processes and scar formation in severe acne. These results point to new genetic susceptibility factors and suggest several new biological pathways related to severe acne.

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