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Review
. 2014 Feb;45(2):645-51.
doi: 10.1161/STROKEAHA.113.002491. Epub 2014 Jan 7.

Evaluating intracranial atherosclerosis rather than intracranial stenosis

Xinyi Leng  1 , Ka Sing Wong, David S Liebeskind
Affiliations
Review

Evaluating intracranial atherosclerosis rather than intracranial stenosis

Xinyi Leng et al. Stroke. 2014 Feb.
No abstract available

Keywords: collateral circulation; fractional flow reserve, myocardial; intracranial arteriosclerosis; neuroimaging.

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Figures

Figure 1
Figure 1
Intracranial plaque and arterial wall imaging by high-resolution MRI. An ICAS lesion located at proximal basilar artery with severe luminal stenosis was identified on time-of-flight MRA (white arrow in Panel A). High-resolution MRI revealed an eccentric atherosclerotic plaque along the anterolateral and posterolateral walls of basilar artery (black arrows in Panels B, C and D). (Courtesy of Professor WH Xu of Peking Union Medical College Hospital, Beijing, China.)
Figure 2
Figure 2
CTA source image (A) showing a right middle cerebral artery stenosis, and the reconstructed CFD models illustrating pressure (B) and flow velocity (C) changes across the lesion. Decreased pressure (B) and increased flow velocity (C) in situ and downstream to the lesion are highlighted with arrows on the CFD models.
Figure 3
Figure 3
The method for measurement of SIR of an ICAS on a MRA maximum intensity projection. SIR of the lesion at right middle cerebral artery is calculated as the ratio of mean signal intensities distal (1,039.6) and proximal (1,340.3) to the lesion, adjusted by the mean background signal intensity (401.1; mean of 409.5 and 392.6), which is (1,039.6 – 401.1) / (1,340.3 – 401.1) = 0.68.
See this image and copyright information in PMC

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