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Review
. 2014 Apr;31(3):193-7.
doi: 10.1007/s10719-013-9516-4. Epub 2014 Jan 8.

GM3 and diabetes

Jin-ichi Inokuchi  1
Affiliations
Review

GM3 and diabetes

Jin-ichi Inokuchi. Glycoconj J. 2014 Apr.

Abstract

We demonstrated the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and GM3 ganglioside in adipocytes and propose a working hypothesis "metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides". It is expected that the development of novel diagnosis of metabolic syndrome by identifying the specific ganglioside species and a therapeutic strategy "membrane microdomain ortho-signaling therapy".

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References

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