Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Dec 23:1:52.
doi: 10.3389/fped.2013.00052.

New paradigms in the pathogenesis of otitis media in children

James Mark Coticchia  1 , Michael Chen  1 , Livjot Sachdeva  1 , Sean Mutchnick  2
Affiliations
Review

New paradigms in the pathogenesis of otitis media in children

James Mark Coticchia et al. Front Pediatr. .

Abstract

Acute otitis media (AOM) is a multifactorial disease with a significant socioeconomic impact. The pathogenesis of AOM is attributed to a variety of well-established internal and extrinsic factors. Recent evidence strongly points to bacterial biofilm formation as an important contributor to this disease entity. The nasopharynx is a likely reservoir for infection with subsequent seeding of pathogens to the middle ear via planktonic shedding. Various modalities have been used to directly detect biofilm formation in the middle ear mucosa of children with AOM. Further insights into this disease may lead to new strategies for prevention and treatment.

Keywords: acute otitis media; biofilms; middle ear infection; otitis media; otitis media with effusion; pathogenesis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Proposed algorithm for RAOM pathogenesis.
See this image and copyright information in PMC

References

    1. Rovers MM, Schilder AG, Zielhuis GA, Rosenfeld RM. Otitis media. Lancet (2004) 363(9407):465–7310.1016/S0140-6736(04)15495-0 - DOI - PubMed
    1. Bluestone C. Definitions, terminology, and classification. In: Rosenfeld RM, Bluestone C, editors. Evidence-Based Otitis Media. Hamilton, ON: BC Decker; (1999). p. 85–103
    1. American Academy of Pediatrics Subcommittee on Management of Acute Otitis Media Diagnosis and management of acute otitis media. Pediatrics (2004) 113(5):1451–6510.1542/peds.113.5.1451 - DOI - PubMed
    1. Coker TR, Chan LS, Newberry SJ, Limbos MA, Suttorp MJ, Shekelle PG, et al. Diagnosis, microbial epidemiology, and antibiotic treatment of acute otitis media in children: a systematic review. JAMA (2010) 304(19):2161–910.1001/jama.2010.1651 - DOI - PubMed
    1. McCaig LF, Besser RE, Hughes JM. Trends in antimicrobial prescribing rates for children and adolescents. JAMA (2002) 287(23):3096–10210.1001/jama.287.23.3096 - DOI - PubMed

LinkOut - more resources