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. 2014 Jan 8:15:6.
doi: 10.1186/1471-2369-15-6.

Factors associated with chronic musculoskeletal pain in patients with chronic kidney disease

Heng-Jung Hsu, Chiung-Hui Yen, Kuang-Hung Hsu, I-Wen Wu, Chin-Chan Lee, Ming-Jui Hung, Chiao-Yin Sun, Chia-Chi Chou, Yung-Chih Chen, Ming-Fang Hsieh, Chun-Yu Chen, Chiao-Ying Hsu, Chi-Jen Tsai, Mai-Szu Wu  1
Affiliations

Factors associated with chronic musculoskeletal pain in patients with chronic kidney disease

Heng-Jung Hsu et al. BMC Nephrol. .

Abstract

Background: Chronic musculoskeletal (MS) pain is common in patients with chronic kidney disease (CKD) undergoing haemodialysis. However, epidemiological data for chronic MS pain and factors associated with chronic MS pain in patients with early- or late-stage CKD who are not undergoing dialysis are limited.

Method: A cross-sectional study to evaluate the prevalence of chronic MS pain and factors associated with chronic MS pain in patients with early- and late-stage CKD who were not undergoing dialysis, was conducted. In addition, the distribution of pain severity among patients with different stages of CKD was evaluated.

Results: Of the 456 CKD patients studied, 53.3% (n = 243/456) had chronic MS pain. Chronic MS pain was independently and significantly associated with hyperuricemia as co-morbidity, as well as with the calcium × phosphate product levels. In CKD patients with hyperuricemia, chronic MS pain showed a negative, independent significant association with diabetes mellitus as a co-morbidity (odds ratio: 0.413, p = 0.020). However, in the CKD patients without hyperuricemia as a co-morbidity, chronic MS pain showed an independent significant association with the calcium × phosphate product levels (odds ratio: 1.093, p = 0.027). Furthermore, stage-5 CKD patients seemed to experience more severe chronic MS pain than patients with other stages of CKD.

Conclusion: Chronic MS pain is common in CKD patients. Chronic MS pain was independently and significantly associated with hyperuricemia as co-morbidity, and with the calcium × phosphate product levels in early- and late-stage CKD patients who were not on dialysis.

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Figures

Figure 1
Figure 1
Flow chart indicates patient enrolment.
Figure 2
Figure 2
The percentage of chronic MS pain in CKD patients; the percentage of mild, moderate and severe chronic MS pain in CKD patients with chronic MS pain. Abbreviations: MS: musculoskeletal, CKD: chronic kidney disease.
Figure 3
Figure 3
The percentage of chronic MS pain was significantly higher in patients with co-morbidity of hyperuricemia rather than without hyperuricemia (76.1% vs. 30.1%).
See this image and copyright information in PMC

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