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. 1987 Apr;20(3-4):149-52.
doi: 10.1007/BF02074654.

Potassium-induced histamine release from mast cells and its inhibition by ketotifen

A Németh, P Magyar, R Herceg, Z Huszti

Potassium-induced histamine release from mast cells and its inhibition by ketotifen

A Németh et al. Agents Actions. 1987 Apr.

Abstract

Potassium chloride induced a dose-dependent release of histamine from rat peritoneal mast cells at concentrations from 5 to 150 mM in the absence of extracellular Ca2+. Potassium concentrations greater than 150 mM produced less histamine release. The release was energy-dependent and was complete within one minute. The histamine liberating effect of KCl could be inhibited by NaCl and by preincubation with ketotifen. The monovalent cations, Rb+ and Cs+ also evoked histamine release, whereas Na+ and Li+ were ineffective.

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