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. 2014 Jan;4(1):19-21.
doi: 10.1158/2159-8290.CD-13-0906.

Climbing RAS, the everest of oncogenes

Mariangela Russo  1 , Federica Di Nicolantonio, Alberto Bardelli
Affiliations

Climbing RAS, the everest of oncogenes

Mariangela Russo et al. Cancer Discov. 2014 Jan.

Abstract

Mutations that activate the small GTP-binding protein KRAS are the most common oncogenic event in human tumors. Thirty years after its discovery, mutant KRAS has yet to be therapeutically conquered.

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