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Meta-Analysis
. 2014:9:85-93.
doi: 10.2147/CIA.S55157. Epub 2013 Dec 31.

Incidence and risk of developing contrast-induced acute kidney injury following intravascular contrast administration in elderly patients

Wei Song  1 , Tuo Zhang  1 , Jun Pu  1 , Linghong Shen  1 , Ben He  1
Affiliations
Meta-Analysis

Incidence and risk of developing contrast-induced acute kidney injury following intravascular contrast administration in elderly patients

Wei Song et al. Clin Interv Aging. 2014.

Abstract

Background: The purpose of this meta-analysis was to evaluate the epidemiology of contrast-induced acute kidney injury (CI-AKI) in the elderly.

Methods: A literature review was undertaken to determine the incidence of CI-AKI in individuals receiving intravascular contrast medium in the hospital setting.

Results: Twenty-two studies with 186,455 patients were identified. The pooled incidence of CI-AKI was 13.6% in 67,831 patients older than 65 years of age (95% confidence interval [CI] 10.1-18.2, I(2) =0.496). The pooled odds ratio of CI-AKI in the elderly was 2.55 (95% CI 1.85-3.52, I(2) =0.34). The high incidence of CI-AKI in the elderly was consistent across different administration route subgroups (intracoronary contrast medium group, 15.5% [95% CI 10.3-22.6]; intravenous contrast medium group, 12.4% [95% CI 8.0-18.8]).

Conclusion: Elderly patients are at greater risk for developing CI-AKI.

Keywords: angiography; contrast-induced acute kidney injury; enhanced computed tomography; epidemiology; meta-analysis.

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Figures

Figure 1
Figure 1
Search flow diagram. Abbreviations: AKI, acute kidney injury; CI-AKI, contrast-induced acute kidney injury; CM, contrast medium; RCT, randomized controlled trial.
Figure 2
Figure 2
Overall incidence of CI-AKI in elderly patients (age ≥65 years). Meta-analysis of administration route stratified by pooling the reported incidences of CI-AKI from individual studies. Abbreviations: CI-AKI, contrast-induced acute kidney injury; IA, intra-arterial; IC, intracoronary; IV, intravenous; n, number of participants.
Figure 3
Figure 3
Odds ratios of CI-AKI in the elderly. (A) Meta-analysis of administration route stratified by pooling the calculated odds ratios based on the incidence of CI-AKI in the elderly and younger groups. (B) Meta-analysis by pooling the reported adjusted odds ratios from individual studies. Abbreviations: AKI, acute kidney injury; CI-AKI, contrast-induced acute kidney injury; CM, contrast medium; RCT, randomized controlled trial; Chi, Chi-square test; CI, confidence interval; df, degrees of freedom; IA, intra-arterial; IC, intracoronary; IV, intravenous; SD, standard deviation; SE, standard error.
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References

    1. Seeliger E, Sendeski M, Rihal CS, Persson PB. Contrast-induced kidney injury: mechanisms, risk factors, and prevention. Eur Heart J. 2012;33:2007–2015. - PubMed
    1. McCullough PA. Contrast-induced acute kidney injury. J Am Coll Cardiol. 2008;51:1419–1428. - PubMed
    1. Mehran R, Aymong ED, Nikolsky E, et al. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: development and initial validation. J Am Coll Cardiol. 2004;44:1393–1399. - PubMed
    1. Zhang T, Shen L, Hu L, He B. Optimal duration of dual-antiplatelet therapy following drug-eluting stent implantation: a meta-analysis. J Clin Pharmacol. 2013;53:345–351. - PubMed
    1. Wallace BC, Schmid CH, Lau J, Trikalinos TA. Meta-Analyst: software for meta-analysis of binary, continuous and diagnostic data. BMC Med Res Methodol. 2009;9:80. - PMC - PubMed

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