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Case Reports
. 2013 Nov;4(11):1318-20.

Prevention of renal damage by treating hyperuricemia

Azar Nickavar  1
Affiliations
Case Reports

Prevention of renal damage by treating hyperuricemia

Azar Nickavar. Int J Prev Med. 2013 Nov.

Abstract

Nephrolithiasis, obstructive renal failure, essential hypertension, and chronic tubulointerstitial nephritis have been considered as the renal complications of hyperuricemia. Massive proteinuria has been rarely reported as the primary manifestation of increased serum uric acid. This is the report of a child presented with proteinuira, hypertension, and glomerular scelrosis secondary to hypouricosuric hyperuricemia, who was treated by uric acid lowering management.

Keywords: Glomerular sclerosis; hypertension; hyperuricemia; proteinuria.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Diffuse global glomeruli sclerosis (×400, PAS stain)
Figure 2
Figure 2
Segmental sclerosis in one glomerule (×400, PAS stain)
See this image and copyright information in PMC

References

    1. Preitner F, Bonny O, Laverrière A, Rotman S, Firsov D, Da Costa A, et al. Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy. Proc Natl Acad Sci. 2009;106:15501–6. - PMC - PubMed
    1. Bellinghieri G, Santoro D, Savica V. Pharmacological treatment of acute and chronic hyperuricemia in kidney diseased patients. Contrib Nephrol. 2005;147:149–60. - PubMed
    1. Van’t Hoff WG. Renal menifestations of metabolic disorders. In: Avner ED, Harmon WE, Niaudet P, Yoshokawa N, editors. Pediatric nephrology. 6th ed. Heidelberg, Germany: Springer-Verlag; 2009. pp. 1219–34.
    1. Nakagawa T, Mazzali M, Kang DH, Sánchez-Lozada LG, Herrera-Acosta J, Johnson RJ. Uric acid: A uremic toxin? Blood Purif. 2006;24:67–70. - PubMed
    1. Williams T, Kimo C, Stine KC, Patrick D, Walker PD, Ilyas M, Wang Y, Richard T, Blaszak RT. A patient with hyperuricemia and renal failure: Answer. Pediatr Nephrol. 2007;22:950–3. - PubMed

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