doi: 10.1016/0006-8993(87)90692-5.
Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain
- PMID: 2440512
- DOI: 10.1016/0006-8993(87)90692-5
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Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain
Brain Res.
.
Abstract
The effect of acute swim stress on the functional activity of the gamma-aminobutyric acid (GABA) receptor/chloride ion channel was studied using an assay to measure 36chloride (36Cl-) uptake into rat brain synaptoneurosomes. Muscimol-stimulated 36Cl- uptake in cerebral cortex, hippocampus, but not cerebellum, was enhanced (increased potency and efficacy) in rats subjected to 10 min of swimming, compared to non-stressed, control rats. The effect of swim stress on the activity of the GABA receptor/Cl ion channel was prevented by adrenalectomy.
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