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. 1987 May 12;411(1):151-5.
doi: 10.1016/0006-8993(87)90692-5.

Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain

R D Schwartz, M J Wess, R Labarca, P Skolnick, S M Paul

Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain

R D Schwartz et al. Brain Res. .

Abstract

The effect of acute swim stress on the functional activity of the gamma-aminobutyric acid (GABA) receptor/chloride ion channel was studied using an assay to measure 36chloride (36Cl-) uptake into rat brain synaptoneurosomes. Muscimol-stimulated 36Cl- uptake in cerebral cortex, hippocampus, but not cerebellum, was enhanced (increased potency and efficacy) in rats subjected to 10 min of swimming, compared to non-stressed, control rats. The effect of swim stress on the activity of the GABA receptor/Cl ion channel was prevented by adrenalectomy.

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