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Comment
. 2014 Mar;91(6):1054-6.
doi: 10.1111/mmi.12514. Epub 2014 Jan 21.

LeuO, a dormant sentinel for SPI-1?

Víctor H Bustamante  1 , Edmundo Calva
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LeuO, a dormant sentinel for SPI-1?

Víctor H Bustamante et al. Mol Microbiol. 2014 Mar.
Free article

Abstract

A new mechanism for the turning-off of gene expression in Salmonella Pathogenicity Island 1 (SPI-1) is proposed by Espinosa and Casadesús, which involves the action of the LeuO quiescent regulator, by two different pathways. A major one through the activation of the hilE gene, where the HilE protein would in turn inactivate HilD, a major positive transcriptional regulator of SPI-1; and a minor HilE-HilD-independent pathway. This could constitute a back-up or an aid for the turn-off of SPI-1 genes mediated by the nucleoid protein H-NS.

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