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. 2014;10(3):566-71.
doi: 10.4161/hv.27490. Epub 2014 Jan 9.

Effectiveness of an Indian-made attenuated influenza A(H1N1)pdm 2009 vaccine: a case control study

Prasad S Kulkarni  1 , Sharad Agarkhedkar  2 , Sanjay Lalwani  3 , Ashish R Bavdekar  4 , Sameer Jog  5 , Sidram K Raut  6 , Varsha Parulekar  7 , Shalaka S Agarkhedkar  2 , Sonali Palkar  3 , Somnath Mangrule  1
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Effectiveness of an Indian-made attenuated influenza A(H1N1)pdm 2009 vaccine: a case control study

Prasad S Kulkarni et al. Hum Vaccin Immunother. 2014.

Abstract

A live attenuated influenza A(H1N1)pdm 2009 vaccine was developed and distributed in India in 2010. We estimated the vaccine effectiveness (VE) against laboratory-confirmed pandemic H1N1 (pH1N1) infections in patients with influenza-like illness who visited five tertiary care hospitals in Pune, India during June-December 2010. Swab specimens were analyzed for influenza pH1N1 by reverse transcriptase polymerase chain reaction (RT-PCR). VE was estimated using the test-negative case-control study design and logistic regression. A total of 784 patients (253 cases, 531 controls) were analyzed. The unadjusted overall VE was 75.5% (95% confidence interval [CI] 42.1-89.7), while the adjusted VE was 76% (95% CI 42.1-89.7). We conclude that the live attenuated influenza A(H1N1)pdm 2009 vaccine was effective in our study population, which has opened prospects for using this platform for trivalent formulations.

Keywords: case control; effectiveness; influenza A(H1N1)pdm 2009; live attenuated vaccine; pandemic.

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