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. 1987 Jul 27;219(2):355-9.
doi: 10.1016/0014-5793(87)80252-1.

Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage-dependent Na+ channel

A Lombet, J N Bidard, M Lazdunski
Free article

Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage-dependent Na+ channel

A Lombet et al. FEBS Lett. .
Free article

Abstract

Binding studies indicate that ciguatoxin and brevetoxin allosterically enhance in a very similar way the binding of [3H]batrachotoxinin A 20-alpha-benzoate to the neuronal Na+ channel protein. Moreover ciguatoxin competitively inhibits the binding of [3H]brevetoxin-3 to rat brain membranes. The affinity of ciguatoxin for the Na+ channel is at least 20-50-times higher than that of brevetoxin. These results indicate that ciguatoxin and brevetoxins act at the same binding site on the sodium channel.

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