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Comment
. 2014 Jan 9;123(2):157-9.
doi: 10.1182/blood-2013-12-541318.

EPCR: holy grail of malaria cytoadhesion?

May Ho  1
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Free article
Comment

EPCR: holy grail of malaria cytoadhesion?

May Ho. Blood. .
Free article

Abstract

In this issue of Blood, Aird et al review recent findings that suggest the endothelial protein C receptor (EPCR), known for its pivotal role in mediating cytoprotection against coagulopathy, proinflammatory cytokines, and vascular permeability, may serve as a receptor for Plasmodium falciparum-infected red blood cells (IRBCs) in the brain. In the process, coagulation is allowed to proceed unchecked and contributes to the pathogenesis of cerebral malaria.

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Comment on

  • Plasmodium falciparum picks (on) EPCR.
    Aird WC, Mosnier LO, Fairhurst RM. Aird WC, et al. Blood. 2014 Jan 9;123(2):163-7. doi: 10.1182/blood-2013-09-521005. Epub 2013 Nov 18. Blood. 2014. PMID: 24246501 Free PMC article. Review.

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