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. 2013 Dec 28;19(48):9383-91.
doi: 10.3748/wjg.v19.i48.9383.

Study of risk factors for gastric cancer by populational databases analysis

Fangio Ferrari  1 , Marco Antonio Moura Reis  1
Affiliations

Study of risk factors for gastric cancer by populational databases analysis

Fangio Ferrari et al. World J Gastroenterol. .

Abstract

Aim: To study the association between the incidence of gastric cancer and populational exposure to risk/protective factors through an analysis of international databases.

Methods: Open-access global databases concerning the incidence of gastric cancer and its risk/protective factors were identified through an extensive search on the Web. As its distribution was neither normal nor symmetric, the cancer incidence of each country was categorized according to ranges of percentile distribution. The association of each risk/protective factor with exposure was measured between the extreme ranges of the incidence of gastric cancer (under the 25(th) percentile and above the 75(th) percentile) by the use of the Mann-Whitney test, considering a significance level of 0.05.

Results: A variable amount of data omission was observed among all of the factors under study. A weak or nonexistent correlation between the incidence of gastric cancer and the study variables was shown by a visual analysis of scatterplot dispersion. In contrast, an analysis of categorized incidence revealed that the countries with the highest human development index (HDI) values had the highest rates of obesity in males and the highest consumption of alcohol, tobacco, fruits, vegetables and meat, which were associated with higher incidences of gastric cancer. There was no significant difference for the risk factors of obesity in females and fish consumption.

Conclusion: Higher HDI values, coupled with a higher prevalence of male obesity and a higher per capita consumption of alcohol, tobacco, fruits, vegetables and meat, are associated with a higher incidence of gastric cancer based on an analysis of populational global data.

Keywords: Environment; Epidemiologic factors; Gastric cancer; Public health; Risk factors.

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Figures

Figure 1
Figure 1
Several of the scatter plots. A: Meat; B: Tobacco; C: Alcohol.
Figure 2
Figure 2
World map of countries with extreme incidences of gastric cancer. Blue: Countries categorized as < P25; Red: Countries categorized as > P75.
Figure 3
Figure 3
Boxplot diagrams of human development index values. the consumption of alcohol, tobacco, fruits, vegetables, legumes, meat and fish; and the prevalence of obesity in males and females among countries with gastric cancer incidences < P25 and > P75.
See this image and copyright information in PMC

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