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. 2013 Dec 28;19(48):9425-31.
doi: 10.3748/wjg.v19.i48.9425.

Overexpression of kallikrein gene 10 is a biomarker for predicting poor prognosis in gastric cancer

Xin Jiao  1 , Hong-Jun Lu  1 , Mi-Mi Zhai  1 , Zhi-Jun Tan  1 , Hai-Ning Zhi  1 , Xiao-Man Liu  1 , Chen-Hao Liu  1 , Da-Peng Zhang  1
Affiliations

Overexpression of kallikrein gene 10 is a biomarker for predicting poor prognosis in gastric cancer

Xin Jiao et al. World J Gastroenterol. .

Abstract

Aim: To analyze the expression of kallikrein gene 10 (KLK10) in gastric cancer and to determine whether KLK10 has independent prognostic value in gastric cancer.

Methods: We studied KLK10 expression in 80 histologically confirmed gastric cancer samples using real-time quantitative reverse transcription-PCR and hK10 expression using immunohistochemistry. Correlations with clinicopathological variables (lymph node metastasis, depth of invasion and histology) and with outcomes (disease-free survival and overall survival) during a median follow-up period of 31 mo were assessed. Gastric cancer tissues were then classified as KLK10 positive or negative.

Results: KLK10 was found to be highly expressed in 57/80 (70%) of gastric cancer samples, while its expression was very low in normal gastric tissues. Positive relationships between KLK10 expression and lymph node metastasis (P = 0.048), depth of invasion (P = 0.034) and histology (P = 0.015) were observed. Univariate survival analysis revealed that gastric cancer patients with positive KLK10 expression had an increased risk for relapse/metastasis and death (P = 0.005 and 0.002, respectively). Cox multivariate analysis indicated that KLK10 was an independent prognostic indicator of disease-free survival and overall survival in patients with gastric cancer.

Conclusion: KLK10 expression is an independent biomarker of unfavorable prognosis in patients with gastric cancer.

Keywords: Gastric cancer; Kallikrein gene 10; Prognostic biomarkers; Survival analysis.

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Figures

Figure 1
Figure 1
Confirmation of the integrity of total RNA.
Figure 2
Figure 2
Immunohistochemical analysis of hK10 protein expression in normal gastric tissues and gastric tumor tissues. A: hK10 protein expression in normal gastric tissues; B: hK10 protein expression in gastric tumor tissues.
Figure 3
Figure 3
Kaplan-Meier survival analysis of disease-free survival (A) and overall survival (B) in gastric cancer patients who were either kallikrein gene 10 positive or kallikrein gene 10 negative. KLK10: Kallikrein gene 10.
See this image and copyright information in PMC

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