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. 2008 Jan;1(1):61-72.
doi: 10.1586/17512433.1.1.61.

Treating malaria in pregnancy in developing countries: priorities in clinical research and drug development

Andrew Vallely  1 , James McCarthy, John Changalucha, Lisa Vallely, Daniel Chandramohan
Affiliations

Treating malaria in pregnancy in developing countries: priorities in clinical research and drug development

Andrew Vallely et al. Expert Rev Clin Pharmacol. 2008 Jan.

Abstract

Reducing the burden of falciparum malaria in pregnancy is an urgent international public health priority but one that involves considerable challenges. The rapidly declining effectiveness of agents known to be safe in pregnancy, and the limited efficacy, safety and pharmacokinetic data available for many other antimalarial drugs, mean that current options for the treatment of both severe and uncomplicated falciparum malaria in pregnancy are limited. This report summarizes the literature on this subject and recommends drug combinations for evaluation in Phase II/III treatment trials in pregnancy.

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