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Comment
. 2014 Jan 8;81(1):1-3.
doi: 10.1016/j.neuron.2013.12.023.

Breaching the blood-brain barrier for drug delivery

Robert D Bell  1 , Michael D Ehlers  2
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Breaching the blood-brain barrier for drug delivery

Robert D Bell et al. Neuron. .
Free article

Abstract

Molecular "hitchhiking" through receptor-mediated transcytosis at the blood-brain barrier is a CNS drug delivery strategy. In this issue of Neuron, Niewoehner et al. (2014) describe a modular anti-transferrin receptor Fab approach for shuttling therapeutic antibodies into the brain.

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