Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2014 Mar 11;63(9):935-7.
doi: 10.1016/j.jacc.2013.10.082. Epub 2014 Jan 8.

Inhibition of proto-oncogene c-Src tyrosine kinase: toward a new antiarrhythmic strategy?

Luisa Mestroni  1 , Duy Thai Nguyen  2
Affiliations
Editorial

Inhibition of proto-oncogene c-Src tyrosine kinase: toward a new antiarrhythmic strategy?

Luisa Mestroni et al. J Am Coll Cardiol. .

Abstract

Cellular-Src (c-Src) encodes a plasma membrane-associated tyrosine protein kinase, which plays a vital role in signaling pathways related to cellular development and carcinogenesis (1,2). It was the first proto-oncogene to be described and is the cellular homologue in humans of the viral oncogene of Rous sarcoma virus, the chicken tumor virus discovered by Peyton Rous in 1911 (3). More recently, c-Src has been implicated in connexin43 (Cx43) remodeling in epicardial border zone myocytes following myocardial infarction (MI) (4).

Keywords: Src; connexin43; gap junctions; myocardial infarction; sudden death.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Scheme of c-Src Kinase Pathway Modulating Cx43
Angiotensin II (Ang II) activates and up-regulates c-Src, which in turn causes a dysregulation and degradation of connexin43 (Cx43) with impaired gap junction function. PP1 inhibits c-Src kinase and interrupts Ang II–mediated Cx43 reduction, myocyte uncoupling, and sudden arrhythmic death. ATR-1 = angiotensin II type 1 receptor; RAS = renin-angiotensin system; VF = ventricular fibrillation; VT = ventricular tachycardia; ZO = zonula-occludens. Reproduced with permission from Sovari et al. (11).
See this image and copyright information in PMC

Comment on

References

    1. Roskoski R., Jr Src protein-tyrosine kinase structure and regulation. Biochem Biophys Res Commun. 2004;324:1155–64. - PubMed
    1. Roskoski R., Jr Src kinase regulation by phosphorylation and dephosphorylation. Biochem Biophys Res Commun. 2005;331:1–14. - PubMed
    1. Martin GS. The hunting of the Src. Nat Rev Mol Cell Biol. 2001;2:467–75. - PubMed
    1. Kieken F, Mutsaers N, Dolmatova E, et al. Structural and molecular mechanisms of gap junction remodeling in epicardial border zone myocytes following myocardial infarction. Circ Res. 2009;104:1103–12. - PMC - PubMed
    1. Beyer EC, Paul DL, Goodenough DA. Connexin family of gap junction proteins. J Membr Biol. 1990;116:187–94. - PubMed

MeSH terms

LinkOut - more resources