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Review
. 2013 May;8(2):149-54.
doi: 10.1159/000350774.

A Brief Overview of the WHO Classification of Breast Tumors, 4th Edition, Focusing on Issues and Updates from the 3rd Edition

Hans-Peter Sinn  1 , Hans Kreipe  2
Affiliations
Review

A Brief Overview of the WHO Classification of Breast Tumors, 4th Edition, Focusing on Issues and Updates from the 3rd Edition

Hans-Peter Sinn et al. Breast Care (Basel). 2013 May.

Abstract
in English, German

The WHO Classification of Tumors of the Breast, 4th edition, is an update to the 3rd edition that was published in 2003, and covers all neoplastic and preneoplastic lesions of the breast. Changes to the 4th edition include new aspects and changes to the terminology that reflect our present-day knowledge of these lesions. Definitions for histopathological diagnosis are complemented by a description of clinical features, epidemiology, macroscopy, genetics, and prognostic and predictive features. In this review of the WHO classification, we have focused on invasive carcinomas, precursor lesions, and some benign epithelial proliferations.

Die vierte Auflage der WHO Klassifikation der Tumoren der Mamma ist ein Update der 2003 erschienenen dritten Auflage und behandelt alle neoplastischen und präneoplastischen Läsionen der Mamma. Die Änderungen der vierten Auflage betreffen neue Aspekte und Änderungen der Terminologie, und spiegeln unser gegenwärtiges Verständnis dieser Läsionen wider. Die histopatholo-gischen Definitionen werden ergänzt um Beschreibungen der klinischen Charakteristika, der Makroskopie, Genetik und prognostischer und prädiktiver Informationen. In dieser Übersicht wird ein Überblick über die invasiven Karzinome, die Vorläuferläsionen und einige benigne Epithelproliferaionen gegeben.

Keywords: Breast Cancer; Diagnostic criteria; Pathology; WHO classification.

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