A 21-year-old student with fever and profound jaundice

doi:10.1371/journal.pntd.0002534

Case Reports

. 2014 Jan 9;8(1):e2534.

doi: 10.1371/journal.pntd.0002534. eCollection 2014.

A 21-year-old student with fever and profound jaundice

Affiliations

¹ Infectious Diseases Unit, Department of Medicine, Jos University Teaching Hospital, Jos, Plateau State, Nigeria ; Faculty of Medical Sciences, University of Jos, Jos, Plateau State, Nigeria.
² Faculty of Medical Sciences, University of Jos, Jos, Plateau State, Nigeria ; Department of Medical Microbiology, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.
³ Leptospirosis Unit, Central Diagnostics Laboratories National Veterinary Research Institute, Vom, Plateau State, Nigeria.
⁴ Infectious Diseases Unit, Department of Medicine, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.
⁵ Department of Medical Microbiology, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.
⁶ Department of Infectious Diseases, Brighton and Sussex University Hospital, Brighton, Southeast England, United Kingdom ; Global Health Programme, Brighton and Sussex University, Brighton, Southeast England, United Kingdom.
⁷ Royal Tropical Institute, KIT Biomedical Research, WHO/FAO/OIE and National Collaborating Center for Reference and research on Leptospirosis, Meibergdreef, Amsterdam, The Netherlands.

PMID: 24416459
PMCID: PMC3886912
DOI: 10.1371/journal.pntd.0002534

Case Reports

A 21-year-old student with fever and profound jaundice

Samson Ejiji Isa et al. PLoS Negl Trop Dis. 2014.

. 2014 Jan 9;8(1):e2534.

doi: 10.1371/journal.pntd.0002534. eCollection 2014.

Affiliations

¹ Infectious Diseases Unit, Department of Medicine, Jos University Teaching Hospital, Jos, Plateau State, Nigeria ; Faculty of Medical Sciences, University of Jos, Jos, Plateau State, Nigeria.
² Faculty of Medical Sciences, University of Jos, Jos, Plateau State, Nigeria ; Department of Medical Microbiology, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.
³ Leptospirosis Unit, Central Diagnostics Laboratories National Veterinary Research Institute, Vom, Plateau State, Nigeria.
⁴ Infectious Diseases Unit, Department of Medicine, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.
⁵ Department of Medical Microbiology, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.
⁶ Department of Infectious Diseases, Brighton and Sussex University Hospital, Brighton, Southeast England, United Kingdom ; Global Health Programme, Brighton and Sussex University, Brighton, Southeast England, United Kingdom.
⁷ Royal Tropical Institute, KIT Biomedical Research, WHO/FAO/OIE and National Collaborating Center for Reference and research on Leptospirosis, Meibergdreef, Amsterdam, The Netherlands.

PMID: 24416459
PMCID: PMC3886912
DOI: 10.1371/journal.pntd.0002534

No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

**Figure 1. Dinger's ring (the opaque ring just below the surface of the semi-solid EMJH media in the tube) seen on the ninth day of culture.**

**Figure 2. Positive microscopic agglutination test (MAT) at a titre of 1∶640.**

**Figure 3. Genetic sequence and evolutionary relationships of the isolate (NigEjiji01) in the *Leptospira* taxa.**
Bor. = *L. borgpetersenii*, Alex. = *L. alexanderi*, Wei. = *L. weilii*, San. = *L. santarosai*, Mey. = *L. meyeri*, Kir. = *L. kirschneri*, Nog. = *L. noguchii*, Int. = *L. interrogans*, Bif. = *L. biflexa*.

See this image and copyright information in PMC

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Leptospirosis as a cause of fever associated with jaundice in the Democratic Republic of the Congo.
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References

1. Jan ter Meulen (2004) Viral haemorrhagic fevers: Yellow fever, Lassa fever, Rift Valley fever, Ebola Marburg fever and Criman-Congo fever. In: Eldryd P, Richard G, David M, Geoffrey G, editors. Principles of Medicine in Africa. 3rd edition. Cambridge: Cambridge University Press. pp. 669–671.
1. David WV, Alan B, Tom S (2010) Flaviviruses (Yellow fever, Dengue, Dengue Hemorrhagic Fever, Japanese Encephalitis, West Nile Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis). In: Mandell LG, Bennett EJ, Dolin R, editors. Principles and Practice of Infectious Diseases. 7th edition. Philadelphia: Elsevier. 2144 p.
1. Peters CJ (2010) Lymphocytic Choriomeningitis Virus, and the South American Hemorrhagic Fevers. In: Mandell LG, Bennett EJ, Dolin R, editors. Principles and Practice of Infectious Diseases. 7th edition. Philadelphia: Elsevier. pp. 3059–3065.
1. Gordon MA, Walsh AL, Chaponda M, Soko D, Mbvwinji M, et al. (2001) Bacteraemia and Mortality among Adult Medical Admissions in Malawi – Predominance of Non-typhi Salmonellae (NTS) and Streptococcus pneumonia. J Infect 42: 44–49. - PubMed
1. Gedebou M, Tassew A, Azene G (1984) Blood culture isolates from Addis Ababa hospital- frequency and antibiotic sensitivities. East Afr Med J 61: 190–196. - PubMed

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[1] Jan ter Meulen (2004) Viral haemorrhagic fevers: Yellow fever, Lassa fever, Rift Valley fever, Ebola Marburg fever and Criman-Congo fever. In: Eldryd P, Richard G, David M, Geoffrey G, editors. Principles of Medicine in Africa. 3rd edition. Cambridge: Cambridge University Press. pp. 669–671.

[2] Jan ter Meulen (2004) Viral haemorrhagic fevers: Yellow fever, Lassa fever, Rift Valley fever, Ebola Marburg fever and Criman-Congo fever. In: Eldryd P, Richard G, David M, Geoffrey G, editors. Principles of Medicine in Africa. 3rd edition. Cambridge: Cambridge University Press. pp. 669–671.

[3] David WV, Alan B, Tom S (2010) Flaviviruses (Yellow fever, Dengue, Dengue Hemorrhagic Fever, Japanese Encephalitis, West Nile Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis). In: Mandell LG, Bennett EJ, Dolin R, editors. Principles and Practice of Infectious Diseases. 7th edition. Philadelphia: Elsevier. 2144 p.

[4] David WV, Alan B, Tom S (2010) Flaviviruses (Yellow fever, Dengue, Dengue Hemorrhagic Fever, Japanese Encephalitis, West Nile Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis). In: Mandell LG, Bennett EJ, Dolin R, editors. Principles and Practice of Infectious Diseases. 7th edition. Philadelphia: Elsevier. 2144 p.

[5] Peters CJ (2010) Lymphocytic Choriomeningitis Virus, and the South American Hemorrhagic Fevers. In: Mandell LG, Bennett EJ, Dolin R, editors. Principles and Practice of Infectious Diseases. 7th edition. Philadelphia: Elsevier. pp. 3059–3065.

[6] Peters CJ (2010) Lymphocytic Choriomeningitis Virus, and the South American Hemorrhagic Fevers. In: Mandell LG, Bennett EJ, Dolin R, editors. Principles and Practice of Infectious Diseases. 7th edition. Philadelphia: Elsevier. pp. 3059–3065.

[7] Gordon MA, Walsh AL, Chaponda M, Soko D, Mbvwinji M, et al. (2001) Bacteraemia and Mortality among Adult Medical Admissions in Malawi – Predominance of Non-typhi Salmonellae (NTS) and Streptococcus pneumonia. J Infect 42: 44–49. - PubMed

[8] Gordon MA, Walsh AL, Chaponda M, Soko D, Mbvwinji M, et al. (2001) Bacteraemia and Mortality among Adult Medical Admissions in Malawi – Predominance of Non-typhi Salmonellae (NTS) and Streptococcus pneumonia. J Infect 42: 44–49. - PubMed

[9] Gedebou M, Tassew A, Azene G (1984) Blood culture isolates from Addis Ababa hospital- frequency and antibiotic sensitivities. East Afr Med J 61: 190–196. - PubMed

[10] Gedebou M, Tassew A, Azene G (1984) Blood culture isolates from Addis Ababa hospital- frequency and antibiotic sensitivities. East Afr Med J 61: 190–196. - PubMed

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A 21-year-old student with fever and profound jaundice

Affiliations

A 21-year-old student with fever and profound jaundice

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Conflict of interest statement

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