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. 2013:2013:746749.
doi: 10.1155/2013/746749. Epub 2013 Dec 12.

Vascular endothelial growth factor receptor-1 expression in breast cancer and its correlation to vascular endothelial growth factor a

Nahida Srabovic  1 , Zlata Mujagic  1 , Jasminka Mujanovic-Mustedanagic  2 , Adaleta Softic  1 , Zdeno Muminovic  2 , Adi Rifatbegovic  3 , Lejla Begic  1
Affiliations

Vascular endothelial growth factor receptor-1 expression in breast cancer and its correlation to vascular endothelial growth factor a

Nahida Srabovic et al. Int J Breast Cancer. 2013.

Abstract

VEGF-A is the most potent angiogenic factor in tumour angiogenesis. Its effects are mediated via two receptors VEGFR-1 and VEGFR-2. Primary aim of our study was to examine the expression of VEGFR-1 in breast cancer and its correlation to VEGF expression, lymph node status, tumour size, histological grade, and hormone receptor status. To examine the VEGFR-1 and VEGF expressions in tumour and surrounding tissue of 51 breast cancer patients, and in healthy breast tissue of 30 benign breast diseases patients, we used three-step immunohistochemical staining. VEGFR-1 and VEGF expressions were significantly increased in breast cancer tumour in relation to surrounding tissue (P < 0.01), and the VEGF expression was significantly increased in lymph node positive breast cancer patients (P < 0.01). VEGFR-1 and VEGF expressions were significantly higher in breast cancer tumour compared with healthy breast tissue (P < 0.01). Significant correlation between VEGF and VEGFR-1 expressions was found (P < 0.05). No significant correlations between VEGF and VEGFR-1 expressions and tumour size, histological grade, and hormone receptor status were found. Increased expression of VEGFR-1 and VEGF in breast cancer tumour and significant correlation between these proteins suggest the possible role of VEGF/VEGFR-1 signalization in breast cancer development, although VEGFR-1 potential prognostic value was not confirmed.

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Figures

Figure 1
Figure 1
Microphotography of breast cancer tumour with strongly immunohistochemical staining for VEGF (brown staining) (HE; ×40).
Figure 2
Figure 2
Microphotography of breast cancer tumour with strongly immunohistochemical staining for VEGFR-1 (brown staining) (HE; ×40).
See this image and copyright information in PMC

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