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. 1987 Jun;55(6):623-6.
doi: 10.1038/bjc.1987.126.

In vitro secretion of human chorionic gonadotrophin by bladder tumour cells

Free PMC article

In vitro secretion of human chorionic gonadotrophin by bladder tumour cells

R K Iles et al. Br J Cancer. 1987 Jun.
Free PMC article

Abstract

Human chorionic gonadotrophin (hCG) and alphafetoprotein (AFP) were measured in culture media from a panel of 29 cell lines including 9 bladder carcinomas, 5 'normal' bladder epithelia, 10 germ cell tumours, and 5 miscellaneous tumours and 'normal' cell lines. In 7 of the 9 bladder carcinomas and 4 of the 5 'normal' bladder epithelia, the media contained hCG at levels ranging from between 34 and 3,600 IU l(-1). All other cell lines, including the 10 germ cell tumour lines gave negative results for hCG. These findings indicate that in vitro secretion of hCG is a common feature of normal and neoplastic bladder transitional epithelia, and support the hypothesis that parts of the genito-urinary epithelium have a potential for hCG production.

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