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. 2014 Feb;184(2):418-30.
doi: 10.1016/j.ajpath.2013.10.012.

Concomitant induction of apoptosis and autophagy by prostate apoptosis response-4 in hypopharyngeal carcinoma cells

Ling-Jung Wang  1 , Peir-Rong Chen  2 , Lee-Ping Hsu  3 , Wen-Lin Hsu  4 , Dai-Wei Liu  4 , Chung-Hsing Chang  5 , Yih-Chih Hsu  6 , Jeng-Woei Lee  7
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Free article

Concomitant induction of apoptosis and autophagy by prostate apoptosis response-4 in hypopharyngeal carcinoma cells

Ling-Jung Wang et al. Am J Pathol. 2014 Feb.
Free article

Abstract

The tumor-suppressive activity of prostate apoptosis response-4 (Par-4) has been demonstrated in a variety of human cancers. In this study, for the first time to our knowledge, we demonstrated that a higher intensity of Par-4 was significantly correlated with a better response in patients with hypopharyngeal carcinoma undergoing radiotherapy alone or concurrent chemoradiotherapy. Mechanistically, an elevated expression of Par-4 induced apoptosis of hypopharyngeal carcinoma cells and sensitized cells toward chemotherapeutic agents or X-ray irradiation. Along with apoptotic incitation, intriguingly, autophagic flux also increased on Par-4 stimulation and contributed to cell death. Moreover, the expressions of multiple common regulators involved in apoptosis and autophagy were regulated by Par-4. Taken together, our results suggested a prognostic role of Par-4 in hypopharyngeal carcinoma and showed novel activity of Par-4 in apoptosis and autophagy induction.

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