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Comment
. 2014 Mar;11(3):130-2.
doi: 10.1038/nrcardio.2013.220. Epub 2014 Jan 14.

Acute coronary syndromes: targeting inflammation-what has the VISTA-16 trial taught us?

Michelle L O'Donoghue  1
Affiliations
Comment

Acute coronary syndromes: targeting inflammation-what has the VISTA-16 trial taught us?

Michelle L O'Donoghue. Nat Rev Cardiol. 2014 Mar.

Abstract

The VISTA-16 trial of varespladib, a secretory phospholipase A2 (sPLA2) inhibitor, in patients with an acute coronary syndrome was terminated prematurely owing to futility and a signal towards harm. Despite these discouraging results, therapies that target inflammation to modify pathways in atherogenesis remain an area of active investigation.

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