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Review
. 2014 Feb;65(2):98-105.
doi: 10.1007/s00105-013-2649-3.

[Retinoids in dermatopharmacology]

[Article in German]
P M Amann  1 , H F Merk, J M Baron
Affiliations
Review

[Retinoids in dermatopharmacology]

[Article in German]
P M Amann et al. Hautarzt. 2014 Feb.

Abstract

Background: Retinoids are important in regulating cell proliferation and differentiation and play an important role in the body, including the skin.

Objectives: Our objective is to review the current medical literature regarding use, effects and side-effects of topical and systemic retinoids used for therapy.

Methods: Pubmed/Medline electronic database was searched for relevant German and English literature.

Results: The group of retinoids used for therapeutic purposes includes both naturally occurring and chemically synthesized vitamin A derivates. Because of their influence on keratinization and epithelial differentiation, as well on the proliferation of benign and malignant keratinocytes, retinoids have found a wide application in the field of dermatopharmacology.

Conclusion: Retinoids are among the most efficacious drugs used in the treatment of dermatological disorders and have a wide range of biological effects. Thorough knowledge about side-effects and comprehensive information for the patient are essential for safe treatment with retinoids.

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