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. 1994 Nov;10(6):686-90.
doi: 10.1007/BF00327960.

Biosynthesis of a trypanocide by Chromobacterium violaceum

N Durán  1 , R V Antonio, M Haun, R A Pilli
Affiliations

Biosynthesis of a trypanocide by Chromobacterium violaceum

N Durán et al. World J Microbiol Biotechnol. 1994 Nov.

Abstract

Radio-isotope studies indicated not only that L-tryptophan can serve as carbon source for synthesis of the trypanocide, violacein by Chromobacterium violaceum (BB-78 strain) but also that isatin and indole 3-acetic acid are both important metabolic intermediates. Using 3-indolyl [2-(14)C] and [1-(14)C] acetic acid, it was found that the carboxylic carbon was not eliminated and that indole-3-acetic acid was incorporated intact into the pigment structure. N-Ethyl(5-hydroxy-indol-3-yl)-2-indolylethylamide is also an important metabolic intermediate in the violacein biosynthesis. This is the first report of a metabolic scheme for violacein synthesis which includes an intermediate other than L-tryptophan.

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