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Review
. 1987 Aug;19(4):341-50.
doi: 10.1007/BF00768537.

Molecular genetics of the VDAC ion channel: structural model and sequence analysis

M Forte, H R Guy, C A Mannella
Review

Molecular genetics of the VDAC ion channel: structural model and sequence analysis

M Forte et al. J Bioenerg Biomembr. 1987 Aug.

Abstract

The voltage-dependent anion-selective channel of the outer mitochondrial membrane provides a unique system in which to study the molecular basis of voltage gating of ion flow. We have cloned and sequenced a cDNA coding for this protein in yeast. From the derived amino acid sequence, we have generated a preliminary model for the secondary structure of the protein which suggests that the protein forms a "beta-barrel" type structure. Comparison of the VDAC amino acid sequence with that of the bacterial porins has indicated that the two classes of molecules appear to be unrelated.

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