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. 2013 Dec;47(6):569-74.
doi: 10.4132/KoreanJPathol.2013.47.6.569. Epub 2013 Dec 24.

Development of six tumors in a sebaceus nevus of jadassohn: report of a case

Serap Gozel  1 , Melahat Donmez  1 , Noyan Can Akdur  1 , Hulya Yikilkan  2
Affiliations

Development of six tumors in a sebaceus nevus of jadassohn: report of a case

Serap Gozel et al. Korean J Pathol. 2013 Dec.

Abstract

Nevus sebaceus of Jadassohn is a congenital cutaneous hamartoma comprised of multiple skin structures. It has the potential to develop into variety of neoplasms of various epidermal adnexal origins. While multiple tumors may occasionally arise, it is unusual for more than four tumors to arise simultaneously within a single sebaceus nevus. Here in, we report a case of a 70-year-old woman with six neoplastic proliferations including a syringocystadenoma papilliferum, pigmented trichoblastoma, tubular apocrine adenoma, sebaceoma, tumors of follicular infundibulum and superficial epithelioma with sebaceus differentiation arising in a long standing nevus sebaceus on the scalp. Our case is extraordinary because a single nevus sebaceus contained six neoplastic proliferations with differentiation toward the folliculosebaceous-apocrine unit.

Keywords: Nevus sebaceous of Jadassohn; Pigmented trichoblastoma; Sebaceous differentiation; Syringocystadenoma papilliferum; Tubular apocrine adenoma.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Syringocystadenoma papilliferum in the superficial part of the lesion. Tubular apocrine adenoma and cystic dilate glands in the deeper part.
Fig. 2
Fig. 2
Syringocystadenoma papilliferum in the superficial part of the lesion. (A) Pigmented trichoblastoma and cystic dilate glands in the deeper part. (B) Pigmented trichoblastoma in the deeper part. (C) Typical features of syringocystadenoma papilliferum. (D) Pigmented trichoblastoma; lobules of basaloid aggregates with peripheral palisading.
Fig. 3
Fig. 3
Tumor of follicular infundibulum. Aggregates of small keratinocytes show multiple connections to the epidermis and form a superficial dermal plaque.
Fig. 4
Fig. 4
Syringocystadenoma papilliferum in the superficial part, pigmented trichoblastoma and sebaceoma in the deeper part.
Fig. 5
Fig. 5
(A) Superficial epithelioma with sebaceus differentiation above the trichoblastoma. (B) Superficial epithelioma with sebaceous differentiation. (C) Sebaceous differentiation in the superficial epithelioma.
See this image and copyright information in PMC

References

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