Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jan 1;1(4):e1.
doi: 10.5037/jomr.2010.1401. eCollection 2011.

The effect of locally delivered doxycycline in the treatment of chronic periodontitis. A clinical and microbiological cohort study

Ioannis Ioannou  1 , Nikolaos Dimitriadis  1 , Konstantinos Papadimitriou  1 , Ioannis Vouros  1 , Dimitra Sakellari  1 , Antonis Konstantinidis  1
Affiliations

The effect of locally delivered doxycycline in the treatment of chronic periodontitis. A clinical and microbiological cohort study

Ioannis Ioannou et al. J Oral Maxillofac Res. .

Abstract

Objectives: To evaluate the efficacy of locally delivered doxycycline as an adjunct to non-surgical treatment with the use of an ultrasonic device compared to scaling and root planing using hand instruments, by means of clinical and microbiological criteria.

Material and methods: Thirty three patients with chronic periodontitis participated in this cohort study and were divided into two groups. Patients in control group received scaling and root planing using hand instruments, whereas patients in control group received ultrasonic debridement and 8.8% doxycycline gel was applied after initial therapy and at 3 months at preselected sites. Clinical recordings concerning probing pocket depth, clinical attachment level, plaque index and gingival bleeding index were performed at baseline, 3 and 6 months after baseline. Subgingival samples were analysed using the "checkerboard" DNA-DNA hybridisation technique for Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola.

Results: Both treatments resulted in significant improvement in all clinical recordings. Six months after the treatment a statistically significant decrease was observed for Porphyromonas gingivalis in both of groups and Treponema denticola in the control group (P < 0.05). No inter-group differences were observed (P < 0.05).

Conclusions: Both treatment modalities provided comparable clinical and microbiological results in the treatment of chronic periodontitis.

Keywords: chronic periodontitis; cohort studies.; debridement; doxycycline; root planing; root scaling.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flowchart of the patients throughout the study.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Haffajee AD, Socransky SS, Gunsolley JC. Systemic anti-infective periodontal therapy. A systematic review. Ann Periodontol. 2003 Dec;8(1):115-81. Review. - DOI - PubMed
    1. Garrett S, Johnson L, Drisko CH, Adams DF, Bandt C, Beiswanger B, Bogle G, Donly K, Hallmon WW, Hancock EB, Hanes P, Hawley CE, Kiger R, Killoy W, Mellonig JT, Polson A, Raab FJ, Ryder M, Stoller NH, Wang HL, Wolinsky LE, Evans GH, Harrold CQ, Arnold RM, Southard GL, et al. Two multi-center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene, and scaling and root planing in the treatment of periodontitis. J Periodontol. 1999 May;70(5):490-503. - DOI - PubMed
    1. Kaldahl WB, Kalkwarf KL, Patil KD, Dyer JK, Bates RE Jr. Evaluation of four modalities of periodontal therapy. Mean probing depth, probing attachment level and recession changes. J Periodontol. 1988 Dec;59(12):783-93. - PubMed
    1. Drisko CH. Nonsurgical periodontal therapy. Periodontol 2000. 2001;25:77-88. Review. - DOI - PubMed
    1. Tunkel J, Heinecke A, Flemmig TF. A systematic review of efficacy of machine-driven and manual subgingival debridement in the treatment of chronic periodontitis. J Clin Periodontol. 2002;29 Suppl 3:72-81; discussion 90-1. Review. - DOI - PubMed

LinkOut - more resources