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. 2014 Mar 1;20(5):1169-78.
doi: 10.1158/1078-0432.CCR-13-2094. Epub 2014 Jan 14.

Interactions of hormone replacement therapy, body weight, and bilateral oophorectomy in breast cancer risk

Yong Cui  1 , Sandra L Deming-Halverson, Alicia Beeghly-Fadiel, Loren Lipworth, Martha J Shrubsole, Alecia M Fair, Xiao-Ou Shu, Wei Zheng
Affiliations

Interactions of hormone replacement therapy, body weight, and bilateral oophorectomy in breast cancer risk

Yong Cui et al. Clin Cancer Res. .

Abstract

Purpose: To examine potential modifying effects of body weight and bilateral oophorectomy on the association of hormone replacement therapy (HRT) with risk of breast cancer, overall and by subtypes according to status of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (Her2) among postmenopausal women.

Experimental design: This analysis included 2,510 postmenopausal white women recruited in the Nashville Breast Health Study, a population-based case-control study of breast cancer. Multivariable logistic regression was used to estimate ORs and 95% confidence intervals (CI) for associations between HRT use and risk of breast cancer overall and by subtypes, adjusted for age and education.

Results: Among women with natural menopause and body mass index (BMI) < 25 kg/m(2), ever-use of HRT was associated with increased breast cancer risk (OR, 1.95; 95% CI, 1.32-2.88). Risk was elevated with duration of HRT use (P for trend = 0.002). Similar association patterns were found for ER(+), ER(+)PR(+), and luminal A cancer subtypes but not ER(-), ER(-)PR(-), and triple-negative cancer. In contrast, ever-HRT use in overweight women (BMI ≥ 25 kg/m(2)) showed no association with risk of breast cancer overall or by subtypes; interaction tests for modifying effect of BMI were statistically significant. Ever-HRT use was associated with decreased breast cancer risk (OR, 0.70; 95% CI, 0.38-1.31) among women with prior bilateral oophorectomy but elevated risk (OR, 1.45; 95% CI, 0.92-2.29) among those with hysterectomy without bilateral oophorectomy (P for interaction = 0.057). Similar associations were seen for virtually all breast cancer subtypes, although interaction tests were statistically significant for ER(+) and luminal A only.

Conclusion: Body weight and bilateral oophorectomy modify associations between HRT use and breast cancer risk, especially the risk of hormone receptor-positive tumors.

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Conflict of interest statement

Conflicts of interest: None of the authors declare any conflicts of interest.

Figures

Figure 1
Figure 1. Flow chart of recruitment
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References

    1. Narod SA. Hormone replacement therapy and the risk of breast cancer. Nat Rev Clin Oncol. 2011;8:669–76. - PubMed
    1. Yager JD, Davidson NE. Estrogen carcinogenesis in breast cancer. N Engl J Med. 2006;354:270–82. - PubMed
    1. Althuis MD, Fergenbaum JH, Garcia-Closas M, Brinton LA, Madigan MP, Sherman ME. Etiology of hormone receptor-defined breast cancer: a systematic review of the literature. Cancer Epidemiol Biomarkers Prev. 2004;13:1558–68. - PubMed
    1. Huang Z, Willett WC, Colditz GA, Hunter DJ, Manson JE, Rosner B, et al. Waist circumference, waist: hip ratio, and risk of breast cancer in the Nurses' Health Study. Am J Epidemiol. 1999;150:1316–24. - PubMed
    1. van den Brandt PA, Spiegelman D, Yaun, Adami HO, Beeson L, Folsom AR, et al. Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol. 2000;152:514–27. - PubMed

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