Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Feb 1;24(3):746-9.
doi: 10.1016/j.bmcl.2013.12.107. Epub 2014 Jan 3.

Synthesis of novel 1,2,3-triazole tagged pyrazolo[3,4-b]pyridine derivatives and their cytotoxic activity

Chavva Kurumurthy  1 , Banda Veeraswamy  1 , Pillalamarri Sambasiva Rao  1 , Gautham Santhosh Kumar  1 , Pamulaparthy Shanthan Rao  1 , Velaturu Loka Reddy  2 , Janapala Venkateswara Rao  2 , Banda Narsaiah  3
Affiliations

Synthesis of novel 1,2,3-triazole tagged pyrazolo[3,4-b]pyridine derivatives and their cytotoxic activity

Chavva Kurumurthy et al. Bioorg Med Chem Lett. .

Abstract

A series of novel 1,2,3-triazole tagged pyrazolo[3,4-b]pyridine derivatives 3 and 4 were prepared respectively starting from 6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine 1 via selective N-propargylation, followed by reaction with diverse substituted alkyl/perfluoroalkyl/aryl/aryl amide azides under Sharpless conditions. All the synthesized compounds 3 and 4 were screened for cytotoxic activity against four human cancer cell lines such as U937, THP-1, HL60 and B16-F10. Compounds 3e, 4g, 4i and 4j which showed promising activity have been identified.

Keywords: 1,2,3-Triazoles; Cytotoxic activity; Propargylation; Pyrazolo[3,4-b]pyridine; Sharpless conditions.

PubMed Disclaimer

Publication types

LinkOut - more resources